Medical: Some Pain Medications May Interact With Anti-Depressants

There is one pain medication that carries a possible risk of increasing seizures when combined with anti-depressants.  The medication is known as Ultram or Tramadol (it can also be called Ultracet when it is combined with Tylenol).

This article and this medical alert explains how the interaction can happen – but keep in mind that certain anti-depressants themselves carry an increased seizure risk (ex. Wellbutrin or bupropion) so their combination with Tramadol needs to be discussed with your doctor.