Archive for March, 2009

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Medical: Pain Medications and Motility? In My Stomach?

March 31, 2009

One of the side effects of pain medications are what we delicately like to call…gastrointestinal issues (GI). They can range from ulcers/inflammation after taking anti-inflammatories (aspirin, ibuprofen) up to and including ’stoppages’ that result from the use of opioids (codeine, vicodin, tramadol).

It is in the second area that patients can find themselves faced with inaccurate information – even from doctors. The rational solution to treating stoppages is to recommend fiber supplements and more water. But that may not work on patients taking pain medications – their problem is that the pain medications paralyze the stomach ‘muscles’ – throwing more ’stuff’ at those muscles can lead to more problems (and in some cases bowel obstructions).  Added to this is that when most doctors think of ‘GI’ complications in connection with pain medications, they only think of constipation. The patient may have other problems associated with opiod use such as delayed gastric emptying (the food stays in your stomach while the rest of the plumbing works fine). Again, tossing more fiber and water into a stomach that cannot process existing food leads to….unpleasant results (gastroparesis).  There is still much misinformation when it comes to managing pain medication side effects.

The solution? This article spells out in detail how to manage GI problems related to opioid use. Simply put – patients should make certain that before they start taking pain medications, that they *are* getting enough fiber and water. Then, as soon as they start taking opioids, they should also take stool softeners every day along with a stimulant laxative every 2-3 days (or as needed.)  And in spite of what many GI doctors claim, the article points out that the use of regular stimulant laxatives to manage opiod side effects will not automatically ‘ruin’ your stomach or bowels and will not make you ‘dependent’ on laxatives forever.

Go here for the full article “Managing Opioid Induced Constipation”

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Forum: Benign Hypermobility Syndrome vs EDS?

March 29, 2009

From the Facebook Ehlers-Danlos Syndrome Forum:

“Professors Bird and Grahame disagree about HMS and EDS hypermobility type. Dr. Grahame suggest they are the same and Dr. Bird believes otherwise….” Read the entire thread here

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Asthma and airways collapse in two heritable disorders of connective tissue (abstract)

March 24, 2009

Asthma and airways collapse in two heritable disorders of connective tissue by A W Morgan, S B Pearson, S Davies, H C Gooi and H A Bird

The purpose of this study  was to investigate whether “there was an increased prevalence of respiratory disorders in both the Hypermobility Syndrome (HMS)/Benign Joint Hypermobility Syndrome (BJHS) and Ehlers–Danlos Syndrome (EDS), compared with the normal population.”

The study concluded that there was: “a significant increase in the frequency of a wide range of respiratory symptoms and reduced exercise tolerance. “   These included “asthmatic symptoms….and atopy….. Pulmonary physiological studies revealed increased lung volumes, impaired gas exchange and an increased tendency of both the lower and upper airways to collapse.”   The study went on to state that  “individuals with HMS/BJHS and EDS have respiratory symptoms in association with various pulmonary physiological abnormalities. The increased … asthma may be due to linkage disequilibrium between the genes causing these conditions or a function of the connective tissue defect itself. In the non-asthmatic population, changes in the mechanical properties of the bronchial airways and lung parenchyma may underlie the observed increased tendency of the airways to collapse.”

(the full abstract is located here)

(and the text of the full article can be ordered here)

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Benign Joint Hypermobility Syndrome: Evaluation, Diagnosis, and Management (abstract)

March 24, 2009

by MAJ Michael R. Simpson, DO, MC, USA From the US Army Health Clinic in Darmstadt, Germany.

This article may of particular interest to both patients and doctors in the Armed Forces.  However the article’s observations are universally applicable.  The study focuses on benign joint hypermobility syndrome (BJHS) which it defines as a “connective tissue disorder with hypermobility in which musculoskeletal symptoms occur in the absence of systemic rheumatologic disease.” The purpose of this study is to point out that while BJHS is well known and has been often discussed “in the rheumatology and orthopedic literature, it has not been discussed in the family medicine literature.”  Why is this important?  Because, as the article explains “most patients with musculoskeletal complaints are first seen by family physicians.”  With primary care physicians as the first line defenders against this disorder, they need to be familiar with recognizing and diagnosing BJHS. And because patients “chief complaint is joint pain”, this means that “BJHS can be easily overlooked and not considered in the differential diagnosis.” The author concludes by recommending the “use of the Brighton criteria to facilitate the diagnosis of BJHS.” As for treatment, the following methods are suggested: “patient education, activity modification, stretching and strengthening exercises for the affected joint, and osteopathic manipulative treatment.”

In short, an helpful first article to take to your primary care physicam.

The complete abstract and a full copy of this article can be downloaded here

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Abnormalities of the lungs and thoracic cage in the Ehlers-Danlos syndrome (abstract)

March 24, 2009
Abnormalities of the lungs and thoracic cage in the Ehlers-Danlos syndrome by J G Ayres, F M Pope, J F Reidy, and T J Clark (1985)

The study took twenty patients with Ehlers-Danlos syndrome with the goal of assessing “the frequency of respiratory abnormalities in this condition.”   Five patients had “one episode of haemoptysis, but none had any defect of coagulation.”  Recurrent sinusitis was noted “notably in those with the type I syndrome.”  In looking deeper into the lung area “two patients had bullous lung disease, one of whom (type IV) had had three pneumothoraces and subsequent pleurodesis; he also had tracheomegaly (the Mounier-Kuhn abnormality).”  The study then went on to focus on  skeletal abnormalities and found minor ones “such as pectus excavatum…..particularly in patients with type IV disease” while “three patients had the straight back syndrome.”  In focusing on lung volumes, the study noted that there “were no consistent spirometric or lung volume abnormalities, but eight patients had a raised gas transfer coefficient (Kco), possibly due to an increased intrapulmonary vascular volume.  The study did qualify this finding by pointing out that there were two other patients  with “very low values of Kco that were unexplained.”

A full copy of this abstract and the article can be found here

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EDS Alert Newsletter No. 30

March 23, 2009

Please feel free to start promoting the EDS Alert Newsletter where ever you think it might help. Note for readers who use RSS feeds – the link to set up your own feed is here.

This is our quarterly round-up of information about Ehlers-Danlos Syndrome (EDS). For more information about me and this newsletter, please look here for Sources of Medical Info and Support Groups.

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